Implantable biomedical devices and biosensors have been widely adopted and developed for clinical for continuous monitoring of patients’ health status. When the biomedical biosensors are introduced to patient’s body, foreign body reaction occurs diminishing immune system, and the body becomes highly vulnerable to bacterial infection and complications. When bacteria adhere to the implants forming impenetrable biofilm to antibiotics, removal and treatment require reoperation accompanied by pain and economic burden. Also, fibrotic capsule due to immune response surrounds the implant hindering detection of bio-signals. Hence, anti-biofouling coating which could prevent adhesion of bacteria and immune cells has been of great interest. However, the durability, and the complex fabrication systems such as high vacuum chamber limited its usage.